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[Química Orgánica]Chemistry For Pharmacy Students


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Imagen IPB

 

AUtor: Lutfun Nahar

Año: 2007

formato: .pdf

peso: 16.42MB

pass: www.chilecomparte.cl

 

Preface ix

1 Introduction 1

1.1 Role of chemistry in modern life

1.2 Physical properties of drug molecules

 

 

2 Atomic structure and bonding

 

 

Atoms, elements and compounds

Atomic structure: orbitals and electronic configurations

Chemical bonding theories: formation of chemical bonds

Electronegativity and chemical bonding

Bond polarity and intermolecular forces

Significance of chemical bonding in drug–receptor interactions

 

3 Stereochemistry

 

 

Stereochemistry: definition

Isomerism

Significance of stereoisomerism in determining drug action and toxicity

Synthesis of chiral molecules

Separation of stereoisomers: resolution of racemic mixtures

Compounds with stereocentres other than carbon

Chiral compounds that do not have a tetrahedral atom with four

different groups

 

4 Organic functional groups

 

 

Organic functional groups: definition and structural features

Hydrocarbons

Alkanes, cycloalkanes and their derivatives

Alkenes and their derivatives

Alkynes and their derivatives

Aromatic compounds and their derivatives

Heterocyclic compounds and their derivatives

Nucleic acids

Amino acids and peptides

Importance of functional groups in determining drug actions and toxicity

Importance of functional groups in determining stability of drugs

 

5 Organic reactions

 

 

Types of organic reaction

Radical reactions: free radical chain reactions

Addition reactions

Elimination reactions: 1,2-elimination or b-elimination

 

 

CONTENTS

Substitution reactions

Hydrolysis

Oxidation–reduction reactions

Pericyclic reactions

 

 

6 Natural product chemistry

 

 

Index

Introduction to natural product drug discovery process

Alkaloids

Carbohydrates

Glycosides

Terpenoids

Steroids

Phenolics

 

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Edited by *Daisyta*
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